(087) Association of ESRα T397C (rs2234693) with Male Infertility: A Meta-analysis

Abstract Introduction Infertility is the incapability to achieve fertilization after a certain period following sexual intercourse without any contraceptive measures which affects 1 in 6 couples. Male factors contribute 50%. The male reproductive system affected by both environmental and genetic factors. Genetics variations include chromosomal aberrations, genomic and/or mitochondrial single gene mutations or polymorphism, multiple polymorphism that result spermatogenic failure. Genetic of key genes might have role infertility. In this regard, estrogen receptor may be an important factor increasing risk men, produced testis Sertoli cell, Leydig cell germ cells play maturation capacitation sperms. action mediated two specific Receptors: Estrogen receptors α (ESRα) β (ESRβ). ESRα present on chromosome 6q25. It consists 8 exons are parted 7 intronic regions having complete size 140 kb. codes for 595 amino acid proteins. most widely studied nucleotide (SNP) T397C (rs2234693). found intron divided 46 bp. Few previously published studies reported association between SNP infertility, while others no association. Objective study aims estimate (rs2234693) Methods PUBMED, CENTRAL, Google Scholar PMC articles were searched, whereas case-control, regarding infertility selected meta-analysis. Results Four finally fulfilled criteria No significant (p > 0.05) was overall, ER alpha based all four models. However, when stratified into ethnic groups, significantly associated with Caucasian group dominant model (CC + CT vs TT: OR= 1.43, 95% CI [1.08-1.91], I2 = 89%) as well recessive CT+TT: 1.34, [1.01-1.76], 0%), whereas, Asian group, only 1.97, [1.58-2.46], 98%) indicated Conclusions linked i.e., homozygous conditions populations. Disclosure